用促黄体生成激素释放激素抗血清抑制前列腺素增强的促黄体生成激素释放

Inhibition of prostaglandin-enhanced release of LH by antiserum to luteinizing hormone releasing hormone.

作者信息

Eskay R L, Warberg J, Porter J C

出版信息

Neuroendocrinology. 1977;24(5-6):353-8. doi: 10.1159/000122722.

Abstract

Prostaglandin E2 (PGE2), PGF2alpha, PGF2beta was infused into a lateral ventricle of the brain of adult male rats, after pretreatment with normal rabbit serum (NRS) or anti-LH-RH serum, and the concentration of LH in arterial plasma was determined. I.v. administration of anti-LH-RH serum 2.5 min prior to the infusion of 2 microgram or 20 microgram of PGE2 significantly inhibited the PGE2-induced rise of plasma LH. Intraventricular infusion of 20 microgram of PGF2alpha or PGF2beta into NRS-pretreated animals caused a marked increase in the plasma LH concentration; whereas, prior i.v. administration of anti-LH-RH serum blocked the PG-induced rise in plasma LH levels. It is concluded that PGE2, PGF2alpha, and PGF2beta stimulate the release of LH primarily by enhancing the release of LH-RH.

摘要

在用正常兔血清（NRS）或抗促黄体生成素释放激素（LH-RH）血清预处理成年雄性大鼠后，将前列腺素E2（PGE2）、前列腺素F2α（PGF2α）、前列腺素F2β（PGF2β）注入其脑侧脑室，并测定动脉血浆中LH的浓度。在注入2微克或20微克PGE2前2.5分钟静脉注射抗LH-RH血清，可显著抑制PGE2诱导的血浆LH升高。向经NRS预处理的动物脑室内注入20微克PGF2α或PGF2β，可使血浆LH浓度显著升高；而预先静脉注射抗LH-RH血清则可阻断PG诱导的血浆LH水平升高。得出的结论是，PGE2、PGF2α和PGF2β主要通过增强LH-RH的释放来刺激LH的释放。