Blane D, Hart C L, Smith G D, Gillis C R, Hole D J, Hawthorne V M
Academic Department of Psychiatry, Charing Cross and Westminster Medical School, London.
BMJ. 1996 Dec 7;313(7070):1434-8. doi: 10.1136/bmj.313.7070.1434.
To investigate strength of associations between risk factors for cardiovascular disease and socioeconomic position during childhood and adulthood.
Cross sectional analysis of status of cardiovascular risk factors and past and present social circumstances.
5645 male participants in the west of Scotland collaborative study, a workplace screening study.
Strength of association between each risk factor for cardiovascular disease (diastolic blood pressure, serum cholesterol concentration, level of recreational physical exercise, cigarette smoking, body mass index, and FEV1 score (forced expiratory volume in one second as percentage of expected value) and social class during childhood (based on father's main occupation) and adulthood (based on own occupation at time of screening).
All the measured risk factors were significantly associated with both father's and own social class (P < 0.05), apart from exercise and smoking (not significantly associated with father's social class) and body mass index (not significantly associated with own social class). For all risk factors except body mass index, the regression coefficient of own social class was larger than the regression coefficient of father's social class. The difference between the coefficients was significant for serum cholesterol concentration, cigarette smoking, body mass index, and FEV1 score (all P < 0.001).
Subjects' status for behavioural risk factors (exercise and smoking) was associated primarily with current socioeconomic circumstances, while status for physiological risk factors (serum cholesterol, blood pressure, body mass index, and FEV1) was associated to varying extents with both past and present socioeconomic circumstances.
调查儿童期和成年期心血管疾病危险因素与社会经济地位之间的关联强度。
对心血管危险因素状况以及过去和当前社会环境进行横断面分析。
苏格兰西部协作研究中的5645名男性参与者,这是一项职场筛查研究。
心血管疾病各危险因素(舒张压、血清胆固醇浓度、休闲体育锻炼水平、吸烟、体重指数以及第一秒用力呼气量(FEV1)评分(一秒用力呼气量占预期值的百分比))与儿童期(基于父亲的主要职业)和成年期(基于筛查时自身职业)社会阶层之间的关联强度。
除锻炼和吸烟(与父亲的社会阶层无显著关联)以及体重指数(与自身社会阶层无显著关联)外,所有测量的危险因素均与父亲的社会阶层和自身的社会阶层显著相关(P < 0.05)。对于除体重指数外的所有危险因素,自身社会阶层的回归系数大于父亲社会阶层的回归系数。血清胆固醇浓度、吸烟、体重指数和FEV1评分的系数差异均具有显著性(均P < 0.001)。
行为危险因素(锻炼和吸烟)的状况主要与当前社会经济环境相关,而生理危险因素(血清胆固醇、血压、体重指数和FEV1)的状况在不同程度上与过去和当前的社会经济环境相关。