Notkola V, Punsar S, Karvonen M J, Haapakoski J
Soc Sci Med. 1985;21(5):517-23. doi: 10.1016/0277-9536(85)90035-8.
In this study, the hypothesis that bad socio-economic conditions in childhood may increase the probability of coronary heart disease in adulthood is examined. The study is based partly on the data of the East-West Study in Finland, which is part of the Seven Countries Study. The study began with 823 men in Eastern Finland and 888 men in Western Finland in 1959. The mortality and morbidity of the cohorts were followed from 1959 to 1974. Risk factors were measured in medical examinations in 1959, 1964, 1969 and 1974. Parents of those included in the sample were traced by using parish registers from 1900 to 1919. Over 90% of those in the East-West Study were found. The parents' socio-economic position (socio-economic conditions in childhood) was determined. According to our findings, the relative risks of coronary death, myocardial infarction and ischemic heart disease are systematically increased for those born landless in East Finland. Variables partly explaining the increased risk were body height and smoking. The effect of cholesterol was negligible.
在本研究中，对童年时期恶劣的社会经济状况可能增加成年后患冠心病概率这一假说进行了检验。该研究部分基于芬兰东西方研究的数据，而芬兰东西方研究是七国研究的一部分。该研究始于1959年，当时芬兰东部有823名男性，芬兰西部有888名男性。对这些队列人群的死亡率和发病率从1959年持续跟踪至1974年。在1959年、1964年、1969年和1974年的体检中测量了危险因素。通过使用1900年至1919年的教区登记簿追踪样本中人员的父母。找到了东西方研究中超过90%的人员。确定了其父母的社会经济地位（童年时期的社会经济状况）。根据我们的研究结果，在东芬兰出生时无土地者患冠心病死亡、心肌梗死和缺血性心脏病的相对风险系统性增加。部分解释风险增加的变量是身高和吸烟。胆固醇的影响可忽略不计。
