大鼠伤口愈合过程中血清和尿液中的羟脯氨酸组分
Hydroxyproline fractions in serum and urine of rats during wound healing.
作者信息
Nagelschmidt M, Struck H
出版信息
Res Exp Med (Berl). 1977 Jul 18;170(3):211-5. doi: 10.1007/BF01851431.
Total hydroxyproline in urine and free hydroxyproline, free and peptide hydroxyproline and protein bound hydroxyproline in serum are measured during wound healing in rats. The free and free+peptide fractions vary in concert with each other and with urine hydroxyproline. Protein bound hydroxyproline fractions take a very different course and behave as an acute phase reactant. The results suggest that protein bound hydroxyproline does not mirror collagen turnover but may be more relevant to C1q or complement metabolism.
在大鼠伤口愈合过程中，对尿液中的总羟脯氨酸以及血清中的游离羟脯氨酸、游离与肽结合的羟脯氨酸和与蛋白质结合的羟脯氨酸进行了测定。游离羟脯氨酸和游离 + 肽部分彼此协同变化，并且与尿液羟脯氨酸也协同变化。与蛋白质结合的羟脯氨酸部分呈现出非常不同的变化过程，表现为一种急性期反应物。结果表明，与蛋白质结合的羟脯氨酸并不能反映胶原蛋白的周转情况，而可能与C1q或补体代谢更相关。
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