Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, PR China.
J Sci Food Agric. 2011 Sep;91(12):2173-9. doi: 10.1002/jsfa.4435. Epub 2011 May 10.
A wound is a clinical entity which often poses problems in clinical practice. The present study was aimed to investigate the wound healing potential of administering marine collagen peptides (MCP) from Chum Salmon skin by using two wound models (incision and excision) in rats.
Ninety-six animals were equally divided into the two wound models and then within each model animals were randomly divided into two groups: vehicle-treated group and 2 g kg(-1) MCP-treated group. Wound closure and tensile strength were calculated. Collagen deposition was assessed by Masson staining and hydroxyproline measurement. Angiogenesis was assessed by immunohistological methods. MCP-treated rats showed faster wound closure and improved tissue regeneration at the wound site, which was supported by histopathological parameters pertaining to wound healing. MCP treatment improved angiogenesis and helped form thicker and better organised collagen fibre deposition compared to vehicle-treated group.
The results show the efficacy of oral MCP treatment on wound healing in animals.
伤口是一种在临床实践中经常出现问题的临床实体。本研究旨在通过使用两种大鼠创伤模型（切口和切除）来研究口服三文鱼皮胶原蛋白肽（MCP）的伤口愈合潜力。
96 只动物平均分为两种创伤模型，然后在每个模型内，动物随机分为两组：载体处理组和 2 g kg(-1) MCP 处理组。计算伤口闭合和拉伸强度。通过 Masson 染色和羟脯氨酸测量评估胶原蛋白沉积。通过免疫组织化学方法评估血管生成。与载体处理组相比，MCP 处理组的大鼠表现出更快的伤口闭合和改善的组织再生，这得到了与伤口愈合相关的组织病理学参数的支持。MCP 治疗可改善血管生成，有助于形成更厚、更有组织的胶原蛋白纤维沉积。
研究结果表明，口服 MCP 治疗对动物的伤口愈合具有疗效。
