咖啡酸苯乙酯对人白血病HL-60细胞的抑制作用。
Inhibitory effect of caffeic acid phenethyl ester on human leukemia HL-60 cells.
作者信息
Chen J H, Shao Y, Huang M T, Chin C K, Ho C T
机构信息
Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers, State University of New Jersey, New Brunswick 08903, USA.
出版信息
Cancer Lett. 1996 Nov 29;108(2):211-4. doi: 10.1016/s0304-3835(96)04425-4.
Caffeic acid phenethyl ester (CAPE) was synthesized from caffeic acid and phenethyl alcohol (ratio 1:5) at room temperature with dicyclohexyl carbodiimide (DCC) as a condensing reagent. The yield was about 38%. CAPE was found to arrest the growth of human leukemia HL-60 cells. It also inhibits DNA, RNA and protein synthesis in HL-60 cells with IC50 of 1.0 microM, 5.0 microM and 1.5 microM, respectively.
咖啡酸苯乙酯（CAPE）由咖啡酸和苯乙醇（比例为1:5）在室温下以二环己基碳二亚胺（DCC）作为缩合试剂合成。产率约为38%。发现CAPE可抑制人白血病HL-60细胞的生长。它还抑制HL-60细胞中的DNA、RNA和蛋白质合成，其IC50分别为1.0微摩尔、5.0微摩尔和1.5微摩尔。
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