Steinsvåg S K, Bjerknes R, Berg O H
Department of Otolaryngology, Head and Neck Surgery, Haukeland University Hospital, Bergen, Norway.
Acta Otolaryngol. 1996 Nov;116(6):868-75. doi: 10.3109/00016489609137943.
Human respiratory mucosa and human granulocytes were exposed to topical nasal steroids in vitro. The preparations containing benzalkonium chloride and benzalkonium chloride alone destroyed the mucosa within 10 days. The same preparations also inhibited human neutrophil actin polymerization, degranulation and oxidative burst in vitro in a time and concentration dependent manner. Preparations without benzalkonium chloride, as well as the steroid compounds themselves, did not have these effects. It is concluded that benzalkonium chloride has toxic effects on human respiratory mucosa and human neutrophils in vitro.
在体外，将人呼吸道黏膜和人粒细胞暴露于局部用鼻用类固醇。含有苯扎氯铵以及单独的苯扎氯铵的制剂在10天内破坏了黏膜。相同的制剂在体外还以时间和浓度依赖性方式抑制人中性粒细胞的肌动蛋白聚合、脱颗粒和氧化爆发。不含苯扎氯铵的制剂以及类固醇化合物本身没有这些作用。得出的结论是，苯扎氯铵在体外对人呼吸道黏膜和人中性粒细胞具有毒性作用。
