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赛洛唑啉滴鼻剂诱发过敏反应:一种非典型的围手术期并发症。

Xylometazoline nasal drops induced anaphylaxis: An atypical perioperative complication.

作者信息

Haldar Rudrashish, Bajwa Sukhminderjit Singh, Kaur Jasleen

机构信息

Department of Anaesthesiology, SGPGI, Lucknow, Uttar Pradesh, India.

Department of Anaesthesia, Gian Sagar Medical College, Banur, Patiala, Punjab, India.

出版信息

J Anaesthesiol Clin Pharmacol. 2017 Jul-Sep;33(3):399-401. doi: 10.4103/0970-9185.173331.

DOI:10.4103/0970-9185.173331
PMID:29109644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5672530/
Abstract

Xylometazoline nasal drops used for nasal decongestion can have side-effect in the form of palpitation, hypertension, headache, and tremors. Anaphylaxis to xylometazoline nasal drops is a relatively unrecognized complication. We encountered a patient posted for tonsillectomy who developed serious anaphylaxis upon administration of a commercially available preparation of xylometazoline nasal drops and required aggressive management for stabilization. Further evaluation and literature search indicated toward the preservative (benzylalkonium chloride) as the cause of this adverse event.

摘要

用于减轻鼻充血的赛洛唑啉滴鼻剂可能会产生心悸、高血压、头痛和震颤等副作用。对赛洛唑啉滴鼻剂过敏是一种相对未被认识到的并发症。我们遇到一名计划进行扁桃体切除术的患者,在使用市售的赛洛唑啉滴鼻剂制剂后发生了严重过敏反应,需要积极治疗以稳定病情。进一步评估和文献检索表明,防腐剂(苯扎氯铵)是这一不良事件的原因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9b7/5672530/806a7f98ff63/JOACP-33-399-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9b7/5672530/352389ffff0c/JOACP-33-399-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9b7/5672530/806a7f98ff63/JOACP-33-399-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9b7/5672530/352389ffff0c/JOACP-33-399-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9b7/5672530/806a7f98ff63/JOACP-33-399-g002.jpg

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J Anaesthesiol Clin Pharmacol. 2017 Jul-Sep;33(3):399-401. doi: 10.4103/0970-9185.173331.
2
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本文引用的文献

1
Anaphylactic reaction following administration of nose drops containing benzalkonium chloride.滴注含有苯扎氯铵的滴鼻剂后发生过敏反应。
Head Face Med. 2012 Oct 18;8:29. doi: 10.1186/1746-160X-8-29.
2
Anaphylaxis to benzalkonium chloride-coated central venous catheter.对苯扎氯铵涂层中心静脉导管的过敏反应。
J Clin Anesth. 2010 Dec;22(8):632-4. doi: 10.1016/j.jclinane.2009.09.017.
3
Anaphylaxis with use of eye-drops containing benzalkonium chloride preservative.使用含有苯扎氯铵防腐剂的眼药水引发过敏反应。
Clin Exp Optom. 2009 Sep;92(5):444-6. doi: 10.1111/j.1444-0938.2009.00395.x. Epub 2009 Jun 22.
4
Allergic reactions in anaesthesia: are suspected causes confirmed on subsequent testing?麻醉中的过敏反应:后续检测是否证实了疑似病因?
Br J Anaesth. 2005 Oct;95(4):468-71. doi: 10.1093/bja/aei198. Epub 2005 Aug 12.
5
Reducing the risk of anaphylaxis during anaesthesia: guidelines for clinical practice.降低麻醉期间过敏反应的风险:临床实践指南
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Nasal toxicity of benzalkonium chloride.
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Adjuvant effect of benzalkonium chloride on the allergen-specific IgE, IgG1 and IgG2a antibody formation in BALB/cJ mice.苯扎氯铵对BALB/cJ小鼠变应原特异性IgE、IgG1和IgG2a抗体形成的佐剂效应。
Basic Clin Pharmacol Toxicol. 2004 Aug;95(2):94-6. doi: 10.1111/j.1742-7843.2004.950210.x.
8
Anaphylaxis caused by benzalkonium in a nebulizer solution.雾化液中苯扎氯铵引起的过敏反应。
J Korean Med Sci. 2004 Apr;19(2):289-90. doi: 10.3346/jkms.2004.19.2.289.
9
Anaphylaxis during the perioperative period.围手术期过敏反应。
Anesth Analg. 2003 Nov;97(5):1381-1395. doi: 10.1213/01.ANE.0000082993.84883.7D.
10
Anaphylaxis during anaesthesia. Results of a two-year survey in France.麻醉期间的过敏反应。法国一项为期两年的调查结果。
Br J Anaesth. 2001 Oct;87(4):549-58. doi: 10.1093/bja/87.4.549.