Froehlich J C, Li T K
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202.
Recent Dev Alcohol. 1993;11:187-205.
A large body of evidence indicates that the endogenous opioid system plays an important role in maintaining alcohol drinking behavior. Research is reviewed indicating that the reinforcing properties of alcohol which lead to continued and repeated bouts of drinking are due, in part, to alcohol-induced activation of the endogenous opioid system. Opioid receptor antagonists decrease alcohol craving, alcohol consumption, and loss of control over drinking. The potential of opioid receptor antagonists to improve treatment outcome in comprehensive relapse prevention programs is discussed.
大量证据表明，内源性阿片系统在维持饮酒行为中起重要作用。本文综述了相关研究，表明酒精导致持续和反复饮酒发作的强化特性部分归因于酒精对内源性阿片系统的激活。阿片受体拮抗剂可减少对酒精的渴望、酒精摄入量以及饮酒失控。本文还讨论了阿片受体拮抗剂在综合预防复发项目中改善治疗效果的潜力。
