Vovk O G, Stanislavchuk N A, Pentiuk A A
Eksp Klin Farmakol. 1996 Mar-Apr;59(2):35-7.
Phenobarbital in a dose of 70 mg/kg (one-time daily intraperitoneal administration for 5 days) promotes naproxen elimination from rat blood and reduces its analgesic activity. Cymetidine (intragastric one-time daily administration in a dose of 100 mg/kg for a week) inhibits naproxen elimination from blood and increases it analgesic effect. Thiamine diphosphate administered intraperitoneally in a dose of 10 mg/kg (one time a day for a week) does not change pharmacokinetic and analgesic effect of naproxene.
剂量为70毫克/千克（每日腹腔注射一次，持续5天）的苯巴比妥可促进萘普生从大鼠血液中清除，并降低其镇痛活性。西咪替丁（每日一次胃内给药，剂量为100毫克/千克，持续一周）可抑制萘普生从血液中清除，并增强其镇痛效果。以10毫克/千克的剂量腹腔注射硫胺二磷酸（每天一次，持续一周）不会改变萘普生的药代动力学和镇痛效果。
