Pentiuk A A, Stanislavchuk N A, Borisenko B A
Farmakol Toksikol. 1989 Jul-Aug;52(4):61-4.
Phenobarbital administered in a dose of 70 mg/kg intraperitoneally (once a day for 4 days) was shown to accelerate ortophen elimination from blood of rats and to decrease its analgesic activity. Administration of cimetidine (100 mg/kg, intragastrically once a day for 5 days), cobalt chloride (10 mg/kg, subcutaneously twice) and thiamine diphosphate (10 mg/kg, intraperitoneally once a day for a week) was found to slow down elimination of ortophen from blood and to enhance its analgesic effect. Cimetidine slows down ortophen elimination from blood of the patients.
腹腔注射剂量为70毫克/千克的苯巴比妥（每天一次，共4天）可加速大鼠血液中ortophen的消除，并降低其镇痛活性。发现给予西咪替丁（100毫克/千克，每天一次经胃内给药，共5天）、氯化钴（10毫克/千克，皮下注射两次）和二磷酸硫胺（10毫克/千克，每天一次腹腔注射，共一周）可减缓ortophen从血液中的消除，并增强其镇痛效果。西咪替丁会减缓患者血液中ortophen的消除。
