Juárez J, Corsi-Cabrera M, del Río-Portilla I
Departamento de Fisiología, Universidad Nacional Autónoma de México, DF, Mexico.
Brain Res. 1995 Oct 2;694(1-2):21-8. doi: 10.1016/0006-8993(95)00725-6.
Pregnant rats were injected either with 2 mg of testosterone propionate or with vehicle on days 14 to 19 of gestation. Ano-genital distance (AGD) and body weight (b.wt.) of the offspring were measured at 10, 20, 30, 45, 60, 75 and 90 days of age. Between 98 and 104 days of age the EEG activity was monopollarly recorded with electrodes implanted in the left and right parietal cortex. Males showed higher interhemispheric correlation than females in delta, theta, alpha] and the total band. Delta relative power (RP) was lower and theta RP was higher in males than in females. These sex differences were eliminated with the prenatal testosterone treatment (PTT), which exerted a masculinizing effect on females. Absolute power (AP) did not show sex differences, but PTT produced an increase in the AP of all bands, except for beta2, regardless of sex. PTT increased the AGD at all ages, except 90 days. This increase was significant only in females at 10, 30, 45, 60 and 75 days of age. PTT increased the b.wt. at all ages, regardless of sex. These data indicate that the organizational action of sex hormones during the prenatal period plays an important role in the establishment of EEG sex differences in the rat.
在妊娠第14至19天，给怀孕大鼠注射2毫克丙酸睾酮或赋形剂。在子代出生后10、20、30、45、60、75和90天时测量其肛殖距（AGD）和体重（b.wt.）。在98至104天时，用植入左右顶叶皮质的电极单极记录脑电图活动。在δ波、θ波、α波和全频段中，雄性大鼠的半球间相关性高于雌性。雄性大鼠的δ波相对功率（RP）较低，θ波RP较高。产前睾酮治疗（PTT）消除了这些性别差异，对雌性产生了雄性化作用。绝对功率（AP）没有显示出性别差异，但PTT使所有频段（除β2频段外）的AP增加，与性别无关。PTT在除90天外的所有年龄段均增加了AGD。这种增加仅在10、30、45、60和75日龄的雌性大鼠中显著。PTT在所有年龄段均增加了体重，与性别无关。这些数据表明，产前性激素的组织作用在大鼠脑电图性别差异的建立中起重要作用。
