Barz D, Staack D, Lehmann R, Stange K, Schnurstein K
Abteilung Transfusionsmedizin, Universität Rostock, Deutschland.
Beitr Infusionsther Transfusionsmed. 1996;33:30-4.
We studied the value of leucocyte depletion of platelet and erythrocyte transfusion by filter for the prevention of alloimmunization. In 109 patients with hematological diseases we detected HLA- and platelet specific antibodies by using lymphocytotoxic and IgG-EIA-Thrombomatch. In 17 of the 109 evaluable patients (16%) HLA-antibodies developed (9 female and 8 male). 16 of the 17 had only HLA-antibodies and 1 patient a platelet specific alloantibody primary immunisation. 15 of 17 with a high-risk of prior immunization induced by pregnancy or other transfusions had a 'secondary alloimmunization'.
我们研究了通过滤器去除血小板和红细胞输血中的白细胞对预防同种免疫的价值。在109例血液病患者中，我们采用淋巴细胞毒试验和IgG - EIA - 血栓配型检测HLA和血小板特异性抗体。在109例可评估患者中，有17例（16%）产生了HLA抗体（9例女性和8例男性）。这17例中的16例仅产生了HLA抗体，1例患者初次免疫产生了血小板特异性同种抗体。17例中有15例因妊娠或其他输血有既往免疫高风险，发生了“继发性同种免疫”。
