Tsvetkov M, Mladenov D, Kumanov Kh
Khirurgiia (Sofiia). 1996;49(1):12-5.
Prostate gland carcinoma is a common and serious disease affecting males. Application of steroid and nonsteroid antiandrogens for the purpose of palliative management of prostate carcinoma dates back to 1973. It is endowed with a dual action-central (antigonadotrophic) and peripheral (antiandrogenic). The preparation is used in the form of monotherapy and as a combined therapeutic approach with the analogues of LHRH or orchiectomy. The obtained results undergo comparative assessment. It is believed that the combination cyproterone acetate with other hormonal preparations or orchiectomy yield optimal results in all groups of patients. One is impressed by the fact that the combination used at the onset of treatment is more effective than late inclusion of the second preparation.
前列腺癌是一种影响男性的常见且严重的疾病。使用甾体和非甾体抗雄激素药物对前列腺癌进行姑息治疗可追溯到1973年。它具有双重作用——中枢性（抗促性腺激素）和外周性（抗雄激素）。该制剂以单一疗法的形式使用，也作为与促黄体生成素释放激素（LHRH）类似物或睾丸切除术联合的治疗方法。对所获得的结果进行比较评估。人们认为，醋酸环丙孕酮与其他激素制剂或睾丸切除术联合使用在所有患者组中都能产生最佳效果。令人印象深刻的是，在治疗开始时使用联合疗法比后期加入第二种制剂更有效。
