Salvestrini F, Oliva G, Mattei F M
Istituto di Clinica Chirurgica, Università degli Studi, Siena.
Minerva Chir. 1996 Jul-Aug;51(7-8):625-8.
Urinary infections represent about 30% of all infections observed within a hospital environment in surgical patients with indwelling catheter. The aim of the research was to assess the effectiveness of ciprofloxacin the prophylaxis of bacteriuria in vesical catheter-bearing patients, during the post-operative period. A comparative investigation was carried out in 33 patients submitted to surgery and carries of vesical catheters during the post-operative period. The patients were divided into 2 group: one group of 23 patients received ciprofloxacin, and a group of 10 patients represented the control group. A urine culture was carried out in every patient before positioning the catheter, and urine cultures were taken every 72 hours; the urethero-vesical portion of the catheter was always submitted to cultural examination after its removal. Patients treated with ciprofloxacin received good protection against Gram- urinary infections, and catheter cultures also demonstrated inhibiting activity with respect to urethral colonisation on the part of Gram- infections. Confirmation of this results in larger series would be an indication for the use of ciprofloxacin in the prophylaxis of urinary infections caused by indwelling vesical catheters in the postoperative period.
在留置导尿管的外科患者中，尿路感染约占医院环境中所有感染的30%。本研究的目的是评估环丙沙星在预防术后膀胱留置导尿管患者菌尿方面的有效性。对33例接受手术并在术后留置膀胱导尿管的患者进行了一项对比研究。患者被分为两组：一组23例患者接受环丙沙星治疗，另一组10例患者作为对照组。在放置导尿管前对每位患者进行尿培养，每72小时进行一次尿培养；导尿管拔除后，其尿道膀胱部分始终进行培养检查。接受环丙沙星治疗的患者对革兰氏阴性菌感染有良好的预防作用，导管培养也显示出对革兰氏阴性菌感染引起的尿道定植有抑制活性。在更大规模的系列研究中证实这一结果，将表明环丙沙星可用于预防术后膀胱留置导尿管引起的尿路感染。
