Bozhko G Kh, Chursina V S, Voloshin P V, Kulabukhov V M
Fiziol Zh (1978). 1990 Nov-Dec;36(6):70-5.
Long-term administration (for three months) of ethanol has been studied for its effect on the composition and synthesis of electrophoretic fractions of soluble proteins of the liver, brain, heart, kidneys and adrenals tissues in the guinea pigs. The obtained data permit supposing that the quantitative redistribution of the fractions under study as influenced by ethanol is due to their aggregation. Most of the studied tissues demonstrate a decrease in specific radioactivity of total proteins and 5 of 8-9 recorded electrophoretic fractions. Only one fraction in the heart and brain has been characterized by an increase of the protein synthesis level. The authors' results and data from literature make it possible to conclude that while analyzing pathogenesis of the chronic intoxication by ethanol and alcoholism the quantitative redistribution of soluble proteins and suppression of their synthesis in various tissues should be taken into account.
研究了豚鼠长期（三个月）给予乙醇对肝脏、大脑、心脏、肾脏和肾上腺组织可溶性蛋白质电泳组分的组成和合成的影响。获得的数据表明，乙醇影响下所研究组分的定量重新分布是由于它们的聚集。大多数所研究的组织显示总蛋白以及8 - 9个记录的电泳组分中的5个的比放射性降低。心脏和大脑中只有一个组分的蛋白质合成水平有所增加。作者的研究结果以及文献数据使得可以得出结论，在分析乙醇慢性中毒和酒精中毒的发病机制时，应考虑到各种组织中可溶性蛋白质的定量重新分布及其合成的抑制。
