Dolina O A, Meĭzerov E E, Blinov A V, Litovchenko V S, Koroleva M V
Vestn Ross Akad Med Nauk. 1994(8):50-2.
The analysis of measurements of early and late components of somatosensory (SSEP) and visual evoked potentials (VEP) in healthy examinees was used to compare the central mechanisms responsible for the analgesic action of moradol, tramal, and nubain. As compared to tramal and nubain, moradol was found to cause a more profound increase in the amplitude of early SSEP components. With this, all three agents were equal in suppressing the amplitude of late SSEP and VEP components. The effects of the drugs on SSEP and VEP, as well as on the sensory and psychoemotional components of human pain perception were also evaluated. The potential features of anesthesiological application of the drugs under study were discussed.
通过对健康受试者体感诱发电位（SSEP）早期和晚期成分以及视觉诱发电位（VEP）测量结果的分析，来比较吗多明、曲马多和纳布啡镇痛作用的中枢机制。与曲马多和纳布啡相比，发现吗多明可使SSEP早期成分的波幅有更显著的增加。与此同时，这三种药物在抑制SSEP和VEP晚期成分的波幅方面效果相当。还评估了这些药物对SSEP和VEP以及对人类疼痛感知的感觉和心理情绪成分的影响。讨论了所研究药物在麻醉学应用中的潜在特点。
