Sjögren C, Ulmsten U
Scand J Urol Nephrol. 1977;11(2):149-54. doi: 10.3109/00365597709179708.
Atropine, emeprone, and PR 197--a new anticholinergic compound--were examined for their possible effects on the rabbit ureter in situ. Ureteral pressure, recorded at two levels simultaneously, and intravesical pressure were studied. The effects of the substances were recorded in both normal (unobstructed) and obstructed ureters. It was found that all the substances, but especially PR 197, produced a fall in the basic intra-ureteral pressure, which was most pronounced in animals with obstructed ureters. PR 197 also temporarily abolished the ureteral peristalsis, while atropine and emeprone did not have this effect.
对阿托品、恩普洛胺以及一种新型抗胆碱能化合物PR 197进行了研究，观察它们对家兔原位输尿管可能产生的影响。同时记录了输尿管两个水平处的压力以及膀胱内压力。研究了这些物质在正常（无梗阻）和梗阻输尿管中的作用。结果发现，所有这些物质，尤其是PR 197，可使输尿管基础压力下降，在输尿管梗阻的动物中这种作用最为明显。PR 197还可暂时消除输尿管蠕动，而阿托品和恩普洛胺则无此作用。
