Kakkos S K, Yarmenitis S D, Kalfarentzos F
Department of Surgery, Medical School of University of Patras, Greece.
Hepatogastroenterology. 1996 Nov-Dec;43(12):1540-3.
BACKGROUND/AIMS: To study the action of intravenously administered erythromycin lactobionate on human gallbladder volume, as a possible preventive method against gallbladder stone formation, in high risk patients such as those in sepsis, long standing fasting periods or those receiving prolonged total parenteral nutrition or octreotide.
Twenty-two volunteers randomized to receive intravenously either erythromycin lactobionate 7 mg per kg (study group) or normal saline (controls). We measured ultrasonographically the gallbladder volume before and at 5, 15, 35, 55, 90, 120 and 180 min after the infusion.
Erythromycin induced a biphasic gallbladder contraction, with maximum contractility at 15 min (10.2%) and between 120 and 180 min (22.6%), compared to normal saline controls. Late contractility was correlated to body mass index (BMI).
Erythromycin activity on gallbladder contraction is proved. Its biphasic action needs further investigation to find the involved mechanism(s). Long term administration is also necessary to test its efficacy in preventing gallbladder dilatation.
背景/目的：研究静脉注射乳糖酸红霉素对人类胆囊容积的作用，作为一种针对败血症、长期禁食、接受长期全胃肠外营养或奥曲肽治疗等高危患者预防胆结石形成的可能方法。
22名志愿者随机分为两组，分别静脉注射每千克体重7毫克乳糖酸红霉素（研究组）或生理盐水（对照组）。我们在输注前以及输注后5、15、35、55、90、120和180分钟通过超声测量胆囊容积。
与生理盐水对照组相比，红霉素引起胆囊双相收缩，在15分钟时收缩力最大（10.2%），在120至180分钟之间收缩力为22.6%。后期收缩力与体重指数（BMI）相关。
证实了红霉素对胆囊收缩有作用。其双相作用需要进一步研究以找出相关机制。长期给药对于测试其预防胆囊扩张的疗效也是必要的。
