Tomizawa Y, Kuroiwa H, Suda T, Muroda N, Ezawa K, Minato K, Dobashi K, Tsuchiya S, Saito R, Mori M
Department of Internal Medicine, General Ota Hospital, Gunma, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1996 Nov;34(11):1249-54.
A 51-year-old man was referred and admitted to our hospital for further examination of an abnormal shadow on a chest X-ray film. One month before admission, a chest X-ray film had shown no abnormality. On admission, chest X-ray films and computed tomograms showed a tumor shadow in the right hilum, obstructive pneumonia in the right upper lobe, and a right-sided pleural effusion. Cytological examination of the pleural offusion revealed adenocarcinoma. The patients was given supportive care. The tumor grew rapidly and by the 13th hospital day it occupied whole right upper lobe. The patient died on the 21st day after admission. The white blood cell count had increased to 26540/mm3 as the adenocarcinoma grew. Serum granulocyte colony-stimulating factor (G-CSF), which increases the number of neutrophils in blood in vivo was examined. The serum G-CSF level reached 112 pg/ml. On immunohistochemical examination, the tumor cells stained positively with anti-G-CSF monoclonal antibody. The growth of this tumor was more rapid than expected for adenocarcinoma of the lung. These findings suggest that G-CSF induced growth of the tumor.
一名51岁男性因胸部X光片上的异常阴影被转诊并入住我院进行进一步检查。入院前一个月，胸部X光片未显示异常。入院时，胸部X光片和计算机断层扫描显示右肺门有肿瘤阴影，右上叶阻塞性肺炎，右侧胸腔积液。胸腔积液的细胞学检查显示为腺癌。给予患者支持治疗。肿瘤生长迅速，到住院第13天时已占据整个右上叶。患者在入院后第21天死亡。随着腺癌的生长，白细胞计数增加到26540/mm³。检测了体内可增加血液中中性粒细胞数量的血清粒细胞集落刺激因子（G-CSF）。血清G-CSF水平达到112 pg/ml。免疫组织化学检查显示，肿瘤细胞用抗G-CSF单克隆抗体染色呈阳性。该肿瘤的生长比肺腺癌预期的要快。这些发现提示G-CSF诱导了肿瘤的生长。
