Hirai A, Saitoh Y
2nd Department of Internal Medicine, Chiba University Medical School.
Nihon Rinsho. 1996 Dec;54(12):3283-8.
Epidemiological studies show that serum uric acid is positively associated with blood pressure levels and that serum uric acid is also a predictor of the development of hypertension in normotensive adults. Several clinical studies revealed that insulin resistance and/or hyperinsulinaemia is associated with hypertension and higher plasma concentrations of uric acid, triglyceride and plasminogen activator inhibitor 1 and with lower HDL cholesterol concentrations. Abnormalities in membrane transport system of sodium and related ions may be associated with impared urinary excretion of uric acid in hyperuricemic patients with hypertension. Several anti-hypertensive drugs have been shown to increase urinary excretion of uric acid and thereby reduce its serum level. Strict salt restriction and weight loss may cause at least in the short-term, adverse metabolic changes including elevated uric acid levels. In hypertensive patients.
流行病学研究表明，血清尿酸与血压水平呈正相关，且血清尿酸也是正常血压成年人发生高血压的一个预测指标。多项临床研究显示，胰岛素抵抗和/或高胰岛素血症与高血压、较高的血浆尿酸、甘油三酯和纤溶酶原激活物抑制剂1浓度以及较低的高密度脂蛋白胆固醇浓度相关。在高血压高尿酸血症患者中，钠及相关离子的膜转运系统异常可能与尿酸排泄受损有关。几种抗高血压药物已被证明可增加尿酸的尿排泄，从而降低其血清水平。严格限制盐摄入和减重至少在短期内可能会导致包括尿酸水平升高在内的不良代谢变化。在高血压患者中。
