Mukand J, Kaplan M, Senno R G, Bishop D S
Department of Rehabilitation Medicine, Southern New England Rehabilitation Center, Providence, RI 02907, USA.
Arch Phys Med Rehabil. 1996 Dec;77(12):1309-11. doi: 10.1016/s0003-9993(96)90198-7.
To evaluate the efficacy of sertraline for treating pathological laughing and crying after stroke.
Case series.
Inpatient rehabilitation units of a community and a tertiary-care hospital.
One patient was a 62-year-old right-handed man who had two strokes approximately 2 years apart and had computed tomography consistent with a cerebral infarct involving the left middle cerebral artery branches in the left parietal lobe. A second patient was a 72-year-old right-handed man who had a right middle cerebral artery infarct. He had a questionable history of depression prior to the stroke.
Both patients had poststroke labile affect that was interfering with their rehabilitation. Sertraline was prescribed.
Pretreatment and posttreatment scores on the Pathological Crying and Laughing Scale and Functional Independent Measure.
Both patients showed significant improvement after taking sertraline-improvement that was reflected in their pretreatment and posttreatment scores on the Pathological Crying and Laughing Scale and Functional Independent Measure. The staff noted improvements in sleeping, eating, social interaction, and therapy participation. Both patients tolerated the sertraline well and had no significant side effects.
评估舍曲林治疗中风后病理性哭笑的疗效。
病例系列。
社区和三级护理医院的住院康复科。
一名患者为62岁右利手男性，约两年内发生两次中风，计算机断层扫描显示符合左侧顶叶左侧大脑中动脉分支的脑梗死。第二名患者是一名72岁右利手男性，患有右侧大脑中动脉梗死。中风前他有可疑的抑郁症病史。
两名患者均有中风后情绪不稳定，影响康复。给予舍曲林治疗。
病理性哭笑量表和功能独立性测量的治疗前和治疗后评分。
两名患者服用舍曲林后均有显著改善，这种改善反映在病理性哭笑量表和功能独立性测量的治疗前和治疗后评分上。工作人员注意到患者在睡眠、饮食、社交互动和治疗参与方面有所改善。两名患者对舍曲林耐受性良好，无明显副作用。
