Smoller J W, Pollack M H, Systrom D, Kradin R L
Department of Psychiatry and Pulmonary, Massachusetts General Hospital, Boston 02114, USA.
Psychosomatics. 1998 Jan-Feb;39(1):24-9. doi: 10.1016/S0033-3182(98)71377-5.
Dyspnea can have a debilitating effect on psychosocial and physical functioning in patients with chronic obstructive airways disease. Previous research has suggested that treatment of concomitant mood or anxiety symptoms can improve dyspnea and exercise intolerance among patients with respiratory disease. The authors report here on a case series of 7 patients with obstructive airways disease who reported improvements in dyspnea after sertraline 25-100 mg/day was added to their medication regimens. Four of the seven patients did not appear to meet syndromal criteria for a mood or anxiety disorder. Subjective improvements in dyspnea may have been related to relief of mood or anxiety symptoms or to direct effects on central respiratory systems. Controlled studies are needed to clarify the potential antidyspneic effects of sertraline.
呼吸困难会对慢性阻塞性气道疾病患者的心理社会和身体功能产生不利影响。先前的研究表明，治疗伴发的情绪或焦虑症状可改善呼吸系统疾病患者的呼吸困难和运动不耐受情况。作者在此报告了一个病例系列，7例阻塞性气道疾病患者在其药物治疗方案中添加25 - 100毫克/天的舍曲林后，呼吸困难症状有所改善。7例患者中有4例似乎不符合情绪或焦虑障碍的综合征标准。呼吸困难的主观改善可能与情绪或焦虑症状的缓解有关，也可能与对中枢呼吸系统的直接作用有关。需要进行对照研究以阐明舍曲林潜在的抗呼吸困难作用。
