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病理性情感的治疗:哭笑反应的变异性。

Treatment of pathological affect: variability of response for laughter and crying.

作者信息

McCullagh S, Feinstein A

机构信息

University of Toronto, Sunnybrook Hospital Site, Ontario, Canada.

出版信息

J Neuropsychiatry Clin Neurosci. 2000 Winter;12(1):100-2. doi: 10.1176/jnp.12.1.100.

DOI:10.1176/jnp.12.1.100
PMID:10678522
Abstract

Pathological laughing and crying (PLC) is increasingly recognized to accompany diverse neurologic conditions, although it remains poorly understood. The authors describe 3 cases of amyotrophic lateral sclerosis (ALS) with an unusual change from a predominance of pathological crying to laughter following drug treatment. Possible explanations for this phenomenon are discussed.

摘要

病理性哭笑(PLC)越来越被认为与多种神经系统疾病有关,尽管对此仍知之甚少。作者描述了3例肌萎缩侧索硬化症(ALS)患者,在药物治疗后出现了一种不寻常的变化,即从以病理性哭为主转变为病理性笑。本文讨论了这一现象的可能解释。

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Treatment of pathological affect: variability of response for laughter and crying.病理性情感的治疗:哭笑反应的变异性。
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引用本文的文献

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Non-motor symptoms in patients with amyotrophic lateral sclerosis: current state and future directions.肌萎缩侧索硬化症患者的非运动症状:现状与未来方向。
J Neurol. 2024 Jul;271(7):3953-3977. doi: 10.1007/s00415-024-12455-5. Epub 2024 May 28.
2
Definitions, phenomenology, diagnosis, and management of the disorders of laughter and crying in amyotrophic lateral sclerosis (ALS): Consensus from ALS and Motor Neuron Disease Scientific Department of the Brazilian Academy of Neurology.定义、现象学、诊断和肌萎缩侧索硬化症(ALS)中哭笑障碍的管理:巴西神经病学学会 ALS 和运动神经元疾病科学部的共识。
Arq Neuropsiquiatr. 2023 Aug;81(8):764-775. doi: 10.1055/s-0043-1771176. Epub 2023 Aug 30.
3
Evaluating the safety and efficacy of dextromethorphan/quinidine in the treatment of pseudobulbar affect.
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Neuropsychiatr Dis Treat. 2014 Jun 26;10:1161-74. doi: 10.2147/NDT.S30713. eCollection 2014.
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5
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