Wang J, Mes-Masson A M, Tonin P N, Provencher D, Eydoux P
Cytogenetics Laboratory, the Montreal Children's Hospital, Departments of Human Genetics and Pathology, McGill University, Montréal, Québec, Canada.
Cancer Genet Cytogenet. 2000 Apr 1;118(1):65-8. doi: 10.1016/s0165-4608(99)00170-3.
Simple numerical chromosome aberrations have been observed in tumorigenesis and may point to indicative initiating or early events in tumorigenesis. We have identified two cases of ovarian carcinomas with trisomy of chromosome 10 using conventional GTG-banding and fluorescence in situ hybridization. This is, to our knowledge, the first report of trisomy 10 as a simple karyotypic abnormality observed in ovarian carcinoma. These results suggest that further studies investigating whether chromosome 10 genes are associated with the pathogenesis of some ovarian tumors are warranted.
在肿瘤发生过程中已观察到简单的染色体数目畸变，这可能指向肿瘤发生过程中具有指示性的起始或早期事件。我们使用传统的GTG显带和荧光原位杂交技术，鉴定出两例10号染色体三体的卵巢癌病例。据我们所知，这是首次报道10号染色体三体作为卵巢癌中观察到的一种简单核型异常。这些结果表明，有必要进一步研究10号染色体基因是否与某些卵巢肿瘤的发病机制有关。
