Yang-Feng T L, Li S B, Leung W Y, Carcangiu M L, Schwartz P E
Department of Human Genetics, Yale University School of Medicine, New Haven, CT 06510-8005.
Int J Cancer. 1991 Jul 9;48(5):678-81. doi: 10.1002/ijc.2910480508.
Cytogenetic analysis was performed on 11 benign and borderline ovarian tumors. Trisomy 12, identified as a sole abnormality in 6 tumors, is likely a specific karyotypic change in different benign and borderline tumors and may well be a primary chromosomal lesion in these tumors. The possible association between amplification of the proto-oncogene K-ras-2 which is located on chromosome 12 and trisomy 12 was investigated. DNA blotting analysis of 64 tumors indicates that trisomy 12 does not seem to be related to K-ras-2 amplification in ovarian tumors. K-ras-2 amplification was observed in 3 high-grade tumors from 3 patients with metastases.
对11例卵巢良性和交界性肿瘤进行了细胞遗传学分析。12号染色体三体在6例肿瘤中被确定为唯一异常，可能是不同良性和交界性肿瘤中的一种特异性核型改变，很可能是这些肿瘤中的原发性染色体病变。研究了位于12号染色体上的原癌基因K-ras-2扩增与12号染色体三体之间的可能关联。对64例肿瘤的DNA印迹分析表明，12号染色体三体似乎与卵巢肿瘤中的K-ras-2扩增无关。在3例有转移的患者的3例高级别肿瘤中观察到了K-ras-2扩增。
