Kluge R, Seese A, Sattler B, Knapp W H
Department of Nuclear Medicine, University of Leipzig, Germany.
Nuklearmedizin. 1996 Dec;35(6):205-11.
This study deals with the effect of the non-uniform attenuation correction method on myocardial tomograms of normal subjects.
A total of 35 patients (20 female, 15 male) without evidence of cardiac disease underwent SPET with and without attenuation correction using a dual head camera and transmission data obtained by two scanning Gd-153 line sources after administration of 400 MBq Tc-99m-tetrofosmin
In non-corrected (NC) stress studies the lowest count rates were found in the inferior segments with mean differences in count rates between maxima and minima of 35.8 +/- 10.8%. In attenuation corrected (AC) images the respective segmental differences averaged only 20.9 +/- 3.3% and the images did not show significant count deficiency in the inferior segments. The effects of correction revealed to be sex dependent, but independent of body mass on average.
AC using the above technique significantly reduces the variability of count rate distribution in normal subjects and improves the preconditions for accurate diagnostic evaluation of coronary artery disease using SPET.
本研究探讨非均匀衰减校正方法对正常受试者心肌断层图像的影响。
35例无心脏病证据的患者（20例女性，15例男性），使用双头相机进行单光子发射计算机断层显像（SPET），分别采集有衰减校正和无衰减校正的图像，并在给予400MBq的锝-99m-替曲膦后，通过两个扫描钆-153线源获得传输数据。
在未校正（NC）的负荷研究中，下壁节段的计数率最低，最大值与最小值之间的计数率平均差异为35.8±10.8%。在衰减校正（AC）图像中，相应节段差异平均仅为20.9±3.3%，且下壁节段未显示明显的计数不足。校正效果显示出与性别有关，但平均而言与体重无关。
使用上述技术进行衰减校正可显著降低正常受试者计数率分布的变异性，并改善使用SPET准确诊断冠状动脉疾病的前提条件。
