Clinical Physiology and Nuclear Medicine Unit, Skåne University Hospital, Lund University, Malmö, Sweden.
BMC Med Imaging. 2011 Oct 3;11:18. doi: 10.1186/1471-2342-11-18.
The American Society of Nuclear Cardiology and the Society of Nuclear Medicine state that incorporation of attenuation-corrected (AC) images in myocardial perfusion scintigraphy (MPS) will improve image quality, interpretive certainty, and diagnostic accuracy. However, commonly used software packages for MPS usually include normal stress databases for non-attenuation corrected (NC) images but not for attenuation-corrected (AC) images. The aim of the study was to develop and compare different normal stress databases for MPS in relation to NC vs. AC images, male vs. female gender, and presence vs. absence of obesity. The principal hypothesis was that differences in mean count values between men and women would be smaller with AC than NC images, thereby allowing for construction and use of gender-independent AC stress database.
Normal stress perfusion databases were developed with data from 126 male and 205 female patients with normal MPS. The following comparisons were performed for all patients and separately for normal weight vs. obese patients: men vs. women for AC; men vs. women for NC; AC vs. NC for men; and AC vs. NC for women.
When comparing AC for men vs. women, only minor differences in mean count values were observed, and there were no differences for normal weight vs. obese patients. For all other analyses major differences were found, particularly for the inferior wall.
The results support the hypothesis that it is possible to use not only gender independent but also weight independent AC stress databases.
美国核医学学会和核医学协会指出，在心肌灌注闪烁显像（MPS）中加入衰减校正（AC）图像将提高图像质量、解释确定性和诊断准确性。然而，MPS 常用的软件包通常包括非衰减校正（NC）图像的正常应激数据库，但不包括衰减校正（AC）图像的正常应激数据库。本研究的目的是开发和比较 MPS 的不同正常应激数据库，涉及 NC 与 AC 图像、男性与女性性别以及肥胖的存在与缺失。主要假设是，男性和女性之间的平均计数值差异在 AC 图像中比在 NC 图像中更小，从而允许构建和使用与性别无关的 AC 应激数据库。
使用 126 名男性和 205 名女性正常 MPS 患者的数据开发正常应激灌注数据库。对所有患者和正常体重与肥胖患者分别进行以下比较：男性与女性的 AC；男性与女性的 NC；男性的 AC 与 NC；女性的 AC 与 NC。
当比较男性的 AC 与女性时，仅观察到平均计数值的微小差异，且正常体重与肥胖患者之间无差异。对于所有其他分析，都发现了明显的差异，特别是在下壁。
结果支持这样一种假设，即不仅可以使用与性别无关，而且可以使用与体重无关的 AC 应激数据库。
