酿酒酵母线粒体缺乏细菌型分泌机制。
Saccharomyces cerevisiae mitochondria lack a bacterial-type sec machinery.
作者信息
Glick B S, Von Heijne G
机构信息
Department of Molecular Genetics and Cell Biology, University of Chicago, Illinois 60637, USA.
出版信息
Protein Sci. 1996 Dec;5(12):2651-2. doi: 10.1002/pro.5560051229.
Abstract
The bacterial Sec genes encode a generalized protein export machinery. Although the mitochondria present in eukaryotic cells are derived from bacterial ancestors, a comprehensive search of the complete genomic sequence for the eukaryotic yeast Saccharomyces cerevisiae did not reveal any close homologs of the bacterial Sec genes, strongly suggesting that yeast mitochondria lack a generalized bacterial-type export system. This finding has implications for the sorting of imported mitochondrial proteins to the intermembrane space compartment, and also for the insertion of mitochondrially encoded proteins into the inner membrane.
摘要
细菌的Sec基因编码一种通用的蛋白质输出机制。尽管真核细胞中的线粒体起源于细菌祖先，但对真核酵母酿酒酵母的完整基因组序列进行全面搜索，并未发现细菌Sec基因的任何紧密同源物，这强烈表明酵母线粒体缺乏通用的细菌型输出系统。这一发现对于将导入的线粒体蛋白分选到膜间隙隔室以及将线粒体编码的蛋白插入内膜都有影响。
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