Garzetti G G, Ciavattini A, Provinciali M, Fabris N, Cignitti M, Romanini C
Department of Obstetrics and Gynecology, University of Ancona, Italy.
Obstet Gynecol. 1993 May;81(5 ( Pt 1)):665-8.
To evaluate the correlation between natural killer cell activity and serum estradiol (E2) levels in patients with different stages of endometriosis.
Natural killer cell activity of peripheral blood lymphocytes and serum E2 levels were evaluated in 73 women who underwent laparoscopy for pelvic pain, infertility, and benign adnexal masses.
The 33 patients (45%) with endometriosis showed a significant decrease in natural killer cell activity in relationship to an increase in disease stage (correlation coefficient r = -0.83, P < .001). A significant inverse relationship was observed between cytotoxicity and serum E2 levels (correlation coefficient r = -0.89, P < .001).
The relationship between natural killer cell activity and serum E2 levels suggests that an immunoendocrine interaction plays an important role in the progression of endometriosis.
评估不同阶段子宫内膜异位症患者自然杀伤细胞活性与血清雌二醇（E2）水平之间的相关性。
对73例因盆腔疼痛、不孕及附件良性肿块而行腹腔镜检查的女性，评估其外周血淋巴细胞的自然杀伤细胞活性及血清E2水平。
33例（45%）子宫内膜异位症患者的自然杀伤细胞活性随疾病分期增加而显著降低（相关系数r = -0.83，P <.001）。细胞毒性与血清E2水平之间存在显著负相关（相关系数r = -0.89，P <.001）。
自然杀伤细胞活性与血清E2水平之间的关系表明，免疫内分泌相互作用在子宫内膜异位症进展中起重要作用。
