克罗恩病患者对铝、硅、钛或锆的氧化物无皮肤敏感性。
Absence of skin sensitivity to oxides of aluminium, silicon, titanium or zirconium in patients with Crohn's disease.
作者信息
Lee J C, Halpern S, Lowe D G, Forbes A, Lennard-Jones J E
机构信息
Department of Dermatology, St Mark's Hospital, London.
出版信息
Gut. 1996 Aug;39(2):231-3. doi: 10.1136/gut.39.2.231.
BACKGROUND
Some metallic compounds, especially of zirconium, can cause cell mediated granulomatous inflammation of the skin. Pigment granules containing compounds of aluminium, silicon, and titanium have been observed within macrophages in the wall of the small intestine in health and in Crohn's disease. Zirconium compounds can be ingested in toothpaste.
AIM
To determine in a pilot study if granulomatous sensitivity can be detected to compounds of these metals or silicon after injection into the skin of patients with Crohn's disease.
SUBJECTS
Eight patients with Crohn's disease known to have had granulomata in the intestine and not currently treated with corticosteroids, and two healthy controls.
METHOD
Two intradermal injections each of 0.1 ml of a 0.02% suspension of one of the compounds made in the abdominal wall of each subject. The site was marked and full thickness skin biopsy performed six weeks later.
RESULT
A foreign body granuloma was observed on histological examination of two biopsy specimens but no evidence of a cell mediated response in any subject.
CONCLUSION
No support was found for the hypothesis that Crohn's disease is due to a specific sensitivity to ingested metallic or silicon compounds.
背景
一些金属化合物，尤其是锆化合物，可引起细胞介导的皮肤肉芽肿性炎症。在健康人和克罗恩病患者的小肠壁巨噬细胞内已观察到含有铝、硅和钛化合物的色素颗粒。锆化合物可通过牙膏摄入。
目的
在一项初步研究中确定对这些金属或硅化合物进行皮内注射后，是否能在克罗恩病患者中检测到肉芽肿敏感性。
对象
8名已知肠道有肉芽肿且目前未接受皮质类固醇治疗的克罗恩病患者，以及2名健康对照者。
方法
在每个受试者的腹壁进行两次皮内注射，每次注射0.1 ml 0.02%的一种化合物悬浮液。标记注射部位，六周后进行全层皮肤活检。
结果
在两份活检标本的组织学检查中观察到异物肉芽肿，但未发现任何受试者有细胞介导反应的证据。
结论
未发现支持克罗恩病是由于对摄入的金属或硅化合物有特异性敏感性这一假说的证据。
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