Liu T, Soong S J
Biostatistics Unit, School of Public Health, University of Alabama at Birmingham, USA.
Surg Clin North Am. 1996 Dec;76(6):1205-22. doi: 10.1016/s0039-6109(05)70511-9.
Descriptive epidemiology of melanoma indicates increases in both incidence and mortality over the past two to three decades. A moderation in both rates began to emerge in several regions after the 1980s, especially in younger age groups. Recent improvement in survival rates is more likely due to earlier diagnosis than to real improvement in treatment. This suggests the potential effectiveness of secondary prevention. Continued health education efforts to improve awareness about signs and symptoms of melanoma should lead to earlier diagnosis and may increase incidence for a certain period of time. However, reduction in mortality will eventually be achieved owing to thinner melanoma at time of diagnosis. Etiologic studies indicate that the most important environmental risk factor for melanoma is extensive exposure to the sun. Primary prevention efforts should target public education about the risk of sun exposure and the benefit of wearing hats and adequate clothing. Specific prevention and control programs should be implemented among high-risk groups, such as those with light complexions and those sensitive to sunburn. In view of the long latency of melanoma, as much as 10 years, past exposure to the risk factors continues to cause melanoma, and any benefits of preventive efforts do not appear for some time. Although a dramatic decline is not expected in melanoma rates immediately, continuous preventive efforts ultimately should lead to a reduction in incidence and mortality.
黑色素瘤的描述性流行病学表明,在过去二三十年中,其发病率和死亡率均有所上升。20世纪80年代后,几个地区的这两种比率开始趋于平稳,尤其是在较年轻的年龄组。近期生存率的提高更可能是由于早期诊断,而非治疗方面的真正改善。这表明二级预防具有潜在成效。持续开展健康教育以提高对黑色素瘤体征和症状的认识,应能实现早期诊断,并可能在一定时期内使发病率上升。然而,由于诊断时黑色素瘤厚度变薄,最终死亡率将会降低。病因学研究表明,黑色素瘤最重要的环境风险因素是过度暴露于阳光下。一级预防措施应致力于对公众进行有关阳光暴露风险以及戴帽子和穿着适当衣物益处的教育。应在高危人群中实施具体的预防和控制方案,如肤色浅的人和易晒伤的人。鉴于黑色素瘤的潜伏期长达10年,过去暴露于风险因素仍会导致黑色素瘤,预防措施的任何益处都不会在短时间内显现。虽然预计黑色素瘤发病率不会立即大幅下降,但持续的预防努力最终应能降低发病率和死亡率。