重度气流受限患者中β2激动剂和抗胆碱能气雾剂的最佳颗粒大小
Optimal particle size for beta 2 agonist and anticholinergic aerosols in patients with severe airflow obstruction.
作者信息
Zanen P, Go L T, Lammers J W
机构信息
Department of Pulmonary Diseases, University Hospital Utrecht, The Netherlands.
出版信息
Thorax. 1996 Oct;51(10):977-80. doi: 10.1136/thx.51.10.977.
BACKGROUND
The optimal particle size of a beta 2 agonist or anticholinergic aerosol in patients with severe airflow obstruction is unknown.
METHODS
Seven stable patients with a mean forced expiratory volume in one second (FEV1) of 37.9% of the predicted value inhaled three types of monodisperse salbutamol and ipratropium bromide aerosols with particle sizes of 1.5 microns, 2.8 microns, and 5 microns, respectively, and a placebo aerosol. The volunteers inhaled 20 micrograms salbutamol and 8 micrograms ipratropium bromide, after which lung function changes were determined and analysed with repeated measurements analysis of variance (ANOVA).
RESULTS
Greater improvements in FEV1, specific airway conductance (sGaw) and maximum expiratory flow at 75%/50% of the forced vital capacity (MEF75/50) were induced by the 2.8 microns aerosol than by the other particle sizes.
CONCLUSIONS
In patients with severe airflow obstruction the particle size of choice for a beta 2 agonist or anticholinergic aerosol should be approximately 3 microns.
背景
在严重气流受限患者中，β2激动剂或抗胆碱能气雾剂的最佳颗粒大小尚不清楚。
方法
7例病情稳定的患者，其一秒用力呼气容积（FEV1）平均为预测值的37.9%，分别吸入三种粒径的单分散沙丁胺醇和异丙托溴铵气雾剂，粒径分别为1.5微米、2.8微米和5微米，以及一种安慰剂气雾剂。志愿者吸入20微克沙丁胺醇和8微克异丙托溴铵，然后测定肺功能变化，并采用重复测量方差分析（ANOVA）进行分析。
结果
与其他粒径的气雾剂相比，2.8微米粒径的气雾剂能使FEV1、比气道传导率（sGaw）和用力肺活量75%/50%时的最大呼气流量（MEF75/50）有更大改善。
结论
在严重气流受限患者中，β2激动剂或抗胆碱能气雾剂的首选颗粒大小应为约3微米。
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