持续输注亚甲蓝治疗感染性休克。
Continuous infusion of methylene blue for septic shock.
作者信息
Brown G, Frankl D, Phang T
机构信息
St Paul's Hospital, Vancouver, British Columbia, Canada.
出版信息
Postgrad Med J. 1996 Oct;72(852):612-4. doi: 10.1136/pgmj.72.852.612.
Abstract
Nitric oxide has been determined to be a potential mediator of the haemodynamic changes associated with sepsis. The haemodynamic eects of nitric oxide can be partially antagonised by methylene blue, through inhibition of the enzyme, guanylate cyclase. The case report presented here demonstrates a beneficial haemodynamic eect of continuous infusion of methylene blue during sepsis. These findings could be extrapolated to other patients or prompt additional research.
摘要
一氧化氮已被确定为与脓毒症相关的血流动力学变化的潜在介质。一氧化氮的血流动力学效应可通过抑制鸟苷酸环化酶，被亚甲蓝部分拮抗。本文所呈现的病例报告表明，脓毒症期间持续输注亚甲蓝具有有益的血流动力学效应。这些发现可外推至其他患者，或促使开展更多研究。
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本文引用的文献
1
Methylene blue inhibits the antithrombotic effect of nitroglycerin.亚甲蓝抑制硝酸甘油的抗血栓形成作用。
J Am Coll Cardiol. 1993 Jan;21(1):255-9. doi: 10.1016/0735-1097(93)90745-m.
2
3
Methylene blue increases myocardial function in septic shock.亚甲蓝可增强感染性休克患者的心肌功能。
Crit Care Med. 1995 Aug;23(8):1363-70. doi: 10.1097/00003246-199508000-00009.
4
Methylene blue administration in septic shock: a clinical trial.亚甲蓝用于感染性休克的临床试验
Crit Care Med. 1995 Feb;23(2):259-64. doi: 10.1097/00003246-199502000-00010.
5
Possible role of nitric oxide in catecholamine secretion by chromaffin cells in the presence and absence of cultured endothelial cells.一氧化氮在有无培养内皮细胞存在的情况下对嗜铬细胞儿茶酚胺分泌的可能作用。
J Neurochem. 1994 Sep;63(3):988-96. doi: 10.1046/j.1471-4159.1994.63030988.x.
6
Methylene blue: effects and disposition in sheep.
J Vet Pharmacol Ther. 1984 Sep;7(3):225-31. doi: 10.1111/j.1365-2885.1984.tb00904.x.
7
Methylene blue inhibits coronary arterial relaxation and guanylate cyclase activation by nitroglycerin, sodium nitrite, and amyl nitrite.亚甲蓝抑制硝酸甘油、亚硝酸钠和亚硝酸异戊酯引起的冠状动脉舒张及鸟苷酸环化酶激活。
Can J Physiol Pharmacol. 1981 Feb;59(2):150-6. doi: 10.1139/y81-025.
8
Methylene blue inhibits the arachidonic acid metabolism in human blood platelets.
Biomed Biochim Acta. 1988;47(10-11):S100-3.
9
Methylene blue for neutralization of heparin.用于中和肝素的亚甲蓝。
Thromb Res. 1989 Jun 15;54(6):677-86. doi: 10.1016/0049-3848(89)90132-1.
10
Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis.
Biochem Biophys Res Commun. 1990 Nov 15;172(3):1132-8. doi: 10.1016/0006-291x(90)91565-a.
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