Laursen E M, Holm K, Brocks V, Jarden M, Müller J
Department of Growth and Reproduction GR, State University Hospital, Rigshospitalet, Copenhagen, Denmark.
Ultrasound Obstet Gynecol. 1996 Nov;8(5):341-5. doi: 10.1046/j.1469-0705.1996.08050341.x.
The aim of this study was to investigate the possible changes in uterine artery flow velocity during puberty and young adulthood. In a cross-sectional study, 133 healthy volunteers aged 6.7 to 25.4 years were investigated. Pubertal development according to the Tanner classification was recorded in each subject. Uterine arteries were visualized by transabdominal color-coded ultrasound. Maximum, minimum and time averaged maximum flow velocities were measured and the pulsatility index (PI) was calculated electronically. When flow velocity was compared between patients at different rates of pubertal development, we found that the average velocity increased from Tanner breast stages I and II to V, followed by a slight decrease in adults (p < 0.0001). The PI varied significantly from stage I to adult (p < 0.0001). The PI was similar in breast stage I, stage II and in adults, with median 4.7 (range 2.7-8.5), 6.1 (range 3.0-7.8) and 4.3 (range 1.9-8.1), respectively. The PI decreased in stages III and IV to 2.6 (1.8-8.4) and 2.8 (1.2-7.9), respectively, whereas stage V was intermediate, at 3.7 (1.1-6.3). The variance of PI was independent of age. In summary, we demonstrated a significant increase in the uterine artery flow velocity during puberty. Furthermore, a significant decline in vascular resistance expressed by the PI was observed in the mid-pubertal period, reflecting increasing blood flow to the rapidly growing uterus.
本研究的目的是调查青春期和青年期子宫动脉血流速度可能发生的变化。在一项横断面研究中，对133名年龄在6.7至25.4岁之间的健康志愿者进行了调查。记录每个受试者根据坦纳分类法的青春期发育情况。通过经腹彩色编码超声观察子宫动脉。测量最大、最小和时间平均最大流速，并通过电子计算搏动指数（PI）。当比较不同青春期发育速率患者之间的流速时，我们发现平均流速从坦纳乳房分期I和II期增加到V期，随后在成年人中略有下降（p<0.0001）。PI从I期到成年期有显著变化（p<0.0001）。PI在乳房I期、II期和成年人中相似，中位数分别为4.7（范围2.7 - 8.5）、6.1（范围3.0 - 7.8）和4.3（范围1.9 - 8.1）。PI在III期和IV期分别降至2.6（1.8 - 8.4）和2.8（1.2 - 7.9），而V期处于中间水平，为3.7（1.1 - 6.3）。PI的方差与年龄无关。总之，我们证明了青春期子宫动脉血流速度显著增加。此外，在青春期中期观察到PI所表示的血管阻力显著下降，反映出流向快速生长子宫的血流量增加。
