黑腹果蝇中的分离畸变：响应者序列的基因组组织
Segregation distortion in Drosophila melanogaster: genomic organization of Responder sequences.
作者信息
Moschetti R, Caizzi R, Pimpinelli S
机构信息
Istituto di Genetica, Università di Bari, Italy.
出版信息
Genetics. 1996 Dec;144(4):1365-71.
Abstract
The heterochromatic Responder (Rsp) locus of Drosophila melanogaster is the target of the two distorter loci Sd and E(SD). Rsp is located in a specific heterochromatic region of the second chromosome and is made up of AT-rich satellite sequences whose abundance is related to its sensitivity to the distorter chromosomes. Here we report that a cluster of Rsp sequences is also located in the third chromosome. The third-chromosome cluster has the same flanking sequences as the clone originally used to identify the Rsp elements, and one of the flanking sequences is a rearranged 412 retrotransposon. The presence of a second, unlinked Rsp-sequence cluster makes re-interpretation necessary for some earlier experiments in which segregation of the third chromosome had not been followed and raises interesting possibilities for the origin of the Rsp locus.
摘要
果蝇黑腹果蝇的异染色质响应者（Rsp）位点是两个畸变位点Sd和E(SD)的作用靶点。Rsp位于第二条染色体的特定异染色质区域，由富含AT的卫星序列组成，其丰度与其对畸变染色体的敏感性有关。我们在此报告，Rsp序列簇也位于第三条染色体上。第三条染色体上的序列簇与最初用于鉴定Rsp元件的克隆具有相同的侧翼序列，其中一个侧翼序列是重排的412反转录转座子。第二个不连锁的Rsp序列簇的存在使得有必要对一些早期实验进行重新解释，在这些实验中没有追踪第三条染色体的分离情况，并且为Rsp位点的起源提出了有趣的可能性。
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