Modigliani E
Service d'endocrinologie, Hôpital Avicenne, Bobigny.
Rev Prat. 1996 Dec 1;46(19):2303-8.
Although rare (10% of thyroid cancers), medullary thyroid cancer is remarkable by the presence of a specific biological marker; elevation of blood calcitonin. It allows its preoperative diagnosis and this extensive surgery which is the only efficient treatment. The possibility of hereditary form (30%) must always be kept in mind; they can now be detected by genetic screening since specific mutations on Ret gene have been recently discovered. Follow up and early treatment of at risk subjects in a family is therefore possible and permits definitive surgical cure.
尽管甲状腺髓样癌很罕见（占甲状腺癌的10%），但它因存在一种特定的生物标志物——血降钙素升高而引人注目。这使得其能够进行术前诊断以及进行作为唯一有效治疗方法的广泛手术。必须始终牢记存在遗传性形式（30%）的可能性；由于最近发现了Ret基因的特定突变，现在可以通过基因筛查来检测它们。因此，对家族中高危个体进行随访和早期治疗是可行的，并且可以实现确定性的手术治愈。
