Roberts S K, Ludwig J, Larusso N F
Department of Biochemistry and Molecular Biology, Mayo Medical School, Clinic and Foundation, Rochester, Minnesota, USA.
Gastroenterology. 1997 Jan;112(1):269-79. doi: 10.1016/s0016-5085(97)70244-0.
Our understanding of the pathobiology of biliary epithelia is rapidly growing because of a surge of investigative activity. This became possible after suitable experimental models and techniques were developed with which to study cholangiocyte biology. Although the molecular mechanisms of bile formation by cholangiocytes and the role of these cells as a major cellular target in a variety of severe hepatobiliary diseases are currently being investigated, many questions remain unanswered, particularly regarding cholangiocellular functions, both in normal and abnormal conditions. As current experimental models become more refined, scientists with interests as diverse as cell biology and physiology, morphology, pharmacology, immunology, genetics, and oncology can be expected to further clarify the pathobiology of biliary epithelia.
由于研究活动激增，我们对胆管上皮细胞病理生物学的理解正在迅速发展。在开发出适合研究胆管细胞生物学的实验模型和技术之后，这才成为可能。尽管目前正在研究胆管细胞形成胆汁的分子机制以及这些细胞在各种严重肝胆疾病中作为主要细胞靶点的作用，但许多问题仍未得到解答，尤其是在正常和异常情况下胆管细胞的功能方面。随着当前实验模型变得更加精细，可以预期，细胞生物学、生理学、形态学、药理学、免疫学、遗传学和肿瘤学等不同领域的科学家将进一步阐明胆管上皮细胞的病理生物学。
