Buchanan N, Bill P, Moodley G, Eyberg C
S Afr Med J. 1977 Aug 27;52(10):394-5.
The half-lives of phenytoin, phenobarbitone and antipyrine were studied in adult Black patients to attempt to ascertain the cause of low phenytoin concentrations previously found in Black epileptics. The following half-life values were observed: antipyrine 5,7 +/- 1,9 hours, phenytoin 15,9 +/- 7,9 hours, phenobarbitone 63,0 +/- 18,2 hours, and phenytoin after 1 month of phenobarbitone therapy 31,5 +/- 11,9 hours. No explanation was obtained for the low phenytoin levels previously observed.
在成年黑人患者中研究了苯妥英、苯巴比妥和安替比林的半衰期，试图确定先前在黑人癫痫患者中发现的苯妥英浓度较低的原因。观察到以下半衰期值：安替比林5.7±1.9小时，苯妥英15.9±7.9小时，苯巴比妥63.0±18.2小时，苯巴比妥治疗1个月后的苯妥英为31.5±11.9小时。对于先前观察到的苯妥英水平较低的情况，未找到解释。
