Mirvis L, Buchanan N, Eyberg C
Intensive Care Med. 1979 May;5(2):69-71. doi: 10.1007/BF01686049.
Antipyrine kinetics were studied in 12 critically ill patients. Antipyrine half life was found to be short (6.5 +/- 3.4 h), this did not alter over 4 days of acute illness, although there was a tendency for antipyrine clearance to decrease over that time period. The need for further pharmacological studies in critically ill patients is stressed.