伴有男性化的产生睾酮的良性囊性畸胎瘤。病例报告。
Testosterone-producing benign cystic teratoma with virilism. A case report.
作者信息
Tomlinson M W, Alaverdian A A, Alaverdian V
机构信息
Department of Obstetrics and Gynecology, Grace Hospital/Wayne State University, Detroit, Michigan 48325, USA.
出版信息
J Reprod Med. 1996 Dec;41(12):924-6.
BACKGROUND
Mature cystic teratomas are common tumors in reproductive-age women. Biologic activity in a small percentage of these neoplasms is well recognized. Thyroid hormone is the most commonly secreted substance.
CASE
A 25-year-old woman presented with a large abdominal mass and virilism. Preoperative evaluation revealed elevated creatinine and testosterone levels and anemia. Computed tomography (CT) showed fat-fluid levels and multiple calcifications within the mass and obstruction of the right kidney. At surgery a 30-cm left ovarian mass was removed. Left ovarian vein testosterone levels were markedly elevated. Pathology reported a mature cystic teratoma. Postoperatively the testosterone levels returned to normal.
CONCLUSION
In rare instances androgen production and virilization may occur with mature cystic teratoma.
背景
成熟囊性畸胎瘤是育龄期女性常见的肿瘤。这些肿瘤中有一小部分具有生物学活性，这一点已得到充分认识。甲状腺激素是最常分泌的物质。
病例
一名25岁女性因腹部巨大肿块和男性化症状就诊。术前评估显示肌酐、睾酮水平升高以及贫血。计算机断层扫描（CT）显示肿块内有脂肪-液体平面和多处钙化，右肾梗阻。手术中切除了一个30厘米的左侧卵巢肿块。左侧卵巢静脉睾酮水平明显升高。病理报告为成熟囊性畸胎瘤。术后睾酮水平恢复正常。
结论
在罕见情况下，成熟囊性畸胎瘤可能会产生雄激素并导致男性化。
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