López-Beltrán A, Calanas A S, Jimena P, Escudero A L, Campello T R, Muñoz-Torres M, Escobar-Jiménez F, Carvia R E, Nogales F F
Department of Pathology, Cordoba University Medical School and Reina Sofia University Hospital, Spain.
Virchows Arch. 1997 Aug;431(2):149-51. doi: 10.1007/s004280050081.
Three further cases of mature benign cystic teratomas of the ovary associated with virilization are added to the three previously reported in the literature. They were found in postmenopausal, obese, diabetic women aged 52, 61, and 67 years. The patients presented with hirsutism and voice changes and clitoromegaly was present in one. Testosterone and androstenedione levels were elevated but promptly regressed after removal of the tumours. Histologically, sheets of stromal luteinized cells were found peripherally at the interface between the neoplasm and ovarian tissue. Luteinization of ovarian stroma induced by an unknown factor related to diabetes mellitus is the origin of the virilization.
又有三例与男性化相关的成熟卵巢良性囊性畸胎瘤病例被补充到先前文献报道的三例中。这些病例发现于绝经后、肥胖的糖尿病女性，年龄分别为52岁、61岁和67岁。患者表现为多毛症和声音改变，其中一例存在阴蒂肥大。睾酮和雄烯二酮水平升高，但肿瘤切除后迅速恢复正常。组织学检查发现，在肿瘤与卵巢组织的界面周围有片状间质黄素化细胞。由与糖尿病相关的未知因素诱导的卵巢间质黄素化是男性化的根源。
