Ray A, Banerjee B D, Sen P
Department of Pharmacology, University College of Medical Sciences (University of Delhi), Shahdara, Delhi, India.
Indian J Exp Biol. 1996 Jul;34(7):698-701.
The effects of A. indica (AI, Neem) were evaluated on tests of humoral and cell-mediated immune responses after 3 weeks of oral AI (leaf extract) treatment in ovalbumin immunized mice. At the dose levels tested, AI (10, 30 or 100 mg/kg), had no appreciable influence on different organ (liver, spleen, thymus)/body weight indices, when compared to controls. In tests for humoral immune responses, AI (100 mg/kg) treated mice had higher (1) IgM and IgG levels, and (b) anti-ovalbumin antibody titres, when compared to the vehicle treated group. In tests for cell-mediated immune responses, there was an enhancement (%) of (a) macrophage migration inhibition, and (b) footpad thickness after AI (100 mg/kg) treatment. These results are discussed in light of the possible immunopotentiating effects of AI.
在卵清蛋白免疫的小鼠中，经3周口服印度楝（AI，印楝）叶提取物治疗后，评估了其对体液免疫和细胞介导免疫反应测试的影响。在所测试的剂量水平下，与对照组相比，AI（10、30或100毫克/千克）对不同器官（肝脏、脾脏、胸腺）/体重指数没有明显影响。在体液免疫反应测试中，与赋形剂处理组相比，AI（100毫克/千克）处理的小鼠具有更高的（1）IgM和IgG水平，以及（b）抗卵清蛋白抗体滴度。在细胞介导免疫反应测试中，AI（100毫克/千克）处理后，（a）巨噬细胞迁移抑制和（b）足垫厚度有所增强（%）。根据AI可能的免疫增强作用对这些结果进行了讨论。
