Korbonits M, Trainer P J, Fanciulli G, Oliva O, Pala A, Dettori A, Besser M, Delitala G, Grossman A B
Department of Endocrinology, St Bartholomew's Hospital, London, UK.
Eur J Endocrinol. 1996 Nov;135(5):543-7. doi: 10.1530/eje.0.1350543.
There is now considerable evidence that nitric oxide is an important neuroregulatory agent, but there has been very little investigation of its possible role in neuroendocrine mechanisms in humans. We have investigated the effects of two nitric oxide precursors, L-arginine and molsidomine, under basal conditions on the pituitary hormones growth hormone (GH), prolactin, luteinizing hormone, follicle-stimulating hormone, thyrotrophin, adrenocorticotrophin (ACTH) and vasopressin, and also on serum cortisol; we have also studied the effect of L-arginine on circulating prolactin, ACTH and cortisol in normal human subjects under hypoglycaemic stress. L-Arginine stimulated both GH and prolactin release under basal conditions but had no effect on the other hormones studied, while the nitric oxide donor molsidomine showed no effect on any hormone studied. L-Arginine potentiated the hypoglycaemia-stimulated release of ACTH but did not influence the rise in GH. The current studies suggest that the effects of L-arginine on the stimulation of GH and prolactin release are unlikely to be mediated via the generation of nitric oxide.
现在有大量证据表明一氧化氮是一种重要的神经调节因子，但对其在人类神经内分泌机制中可能发挥的作用却鲜有研究。我们研究了两种一氧化氮前体，即L-精氨酸和莫西多明，在基础条件下对垂体激素生长激素（GH）、催乳素、黄体生成素、卵泡刺激素、促甲状腺激素、促肾上腺皮质激素（ACTH）和血管加压素的影响，以及对血清皮质醇的影响；我们还研究了L-精氨酸对正常人类受试者在低血糖应激下循环催乳素、ACTH和皮质醇的影响。L-精氨酸在基础条件下刺激了GH和催乳素的释放，但对其他所研究的激素没有影响，而一氧化氮供体莫西多明对所研究的任何激素都没有影响。L-精氨酸增强了低血糖刺激的ACTH释放，但不影响GH的升高。目前的研究表明，L-精氨酸对GH和催乳素释放的刺激作用不太可能通过一氧化氮的生成来介导。
