Hashimoto M, Kobayashi T, Nigi H, Saito S, Nakayama I, Narita T, Iwata M, Yasueda H, Taniguchi Y, Kurimoto M, Inouye S, Sakaguchi M
Division of Wild Animal Medicine, Nippon Veterinary and Animal Science University, Tokyo, Japan.
Int Arch Allergy Immunol. 1997 Jan;112(1):88-92. doi: 10.1159/000237436.
We examined the responses of two Japanese monkeys with pollinosis to two major allergens (Cry j 1 and Cry j 2) of Japanese cedar pollen. The two monkeys (A and B) had specific IgE antibodies to the allergens and showed a strong positive reaction to both of them in the intradermal test. In the histamine release test with peripheral blood mononuclear cells (PBMC), monkey A showed a typical pattern similar to that seen in human patients, while monkey B released a low level of histamine. The proliferative response of PBMC to both allergens in monkey A was weak, but was typical in monkey B. From clinical as well as immunological points of view, these monkeys may be a suitable animal model for Japanese cedar pollinosis in humans.
