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1
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Immunology. 1999 Jun;97(2):348-51. doi: 10.1046/j.1365-2567.1999.00792.x.
2
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Analysis of sequential immunoglobulin E-binding epitope of Japanese cedar pollen allergen (Cry j 2) in humans, monkeys and mice.日本柳杉花粉过敏原（Cry j 2）在人、猴和小鼠中的连续免疫球蛋白E结合表位分析。
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本文引用的文献

1
T cell epitopes in Japanese cedar (Cryptomeria japonica) pollen allergens: choice of major T cell epitopes in Cry j 1 and Cry j 2 toward design of the peptide-based immunotherapeutics for the management of Japanese cedar pollinosis.日本柳杉花粉过敏原中的T细胞表位：Cry j 1和Cry j 2中主要T细胞表位的选择，用于设计基于肽的免疫疗法来治疗日本柳杉花粉症。
J Immunol. 1998 Jul 1;161(1):448-57.
2
Epitope specificity of IgE antibodies to a major allergen (Cry j 1) of Japanese cedar pollen in sera of humans and monkeys with pollinosis.人类和患有花粉症的猴子血清中针对日本柳杉花粉主要过敏原（Cry j 1）的IgE抗体的表位特异性
Immunology. 1997 Jun;91(2):161-6. doi: 10.1046/j.1365-2567.1997.00255.x.
3
Responses of monkeys with pollinosis to two major allergens of Japanese cedar pollen.
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Immunodominance of seven regions of a major allergen, Cry j 2, of Japanese cedar pollen for T-cell immunity.
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Sensitivity to two major allergens (Cry j I and Cry j II) in patients with Japanese cedar (Cryptomeria japonica) pollinosis.
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6
Prevalence of IgE antibody to crude and purified allergens of Japanese cedar pollen among different troops of Japanese monkeys (Macaca fuscata).日本猕猴（猕猴属）不同群体中针对日本柳杉花粉粗提物和纯化过敏原的IgE抗体患病率。
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7
Isolation and partial characterization of the major allergen from Japanese cedar (Cryptomeria japonica) pollen.日本柳杉（Cryptomeria japonica）花粉主要过敏原的分离及部分特性分析
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8
Studies of prevalence of Japanese cedar pollinosis among the residents in a densely cultivated area.对一个密集种植区居民中日本雪松花粉症患病率的研究。
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9
[Investigation into the frequency of cases with Japanese cedar pollinosis among the students and staff members in our university].[我校学生和教职员工中日本雪松花粉症病例的频率调查]
Arerugi. 1990 May;39(5):476-82.
10
Identification of the second major allergen of Japanese cedar pollen.
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一群日本猕猴中日本柳杉花粉症的发病率及对花粉过敏原的致敏情况。

The incidence of japanese cedar pollinosis and sensitization to the pollen allergens among Japanese monkeys in a troop.

作者信息

Sakaguchi M, Kobayashi C, Inouye S, Saito S, Hirahara K, Shiraishi A, Konaka A, Yamada T, Nigi H

机构信息

Department of Immunology, National Institute of Infectious Diseases, Toyama, Tokyo, Japan.

出版信息

Immunology. 1999 Jun;97(2):348-51. doi: 10.1046/j.1365-2567.1999.00792.x.

DOI:10.1046/j.1365-2567.1999.00792.x
PMID:10447752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2326834/
Abstract

The natural occurrence of Japanese cedar (Cryptomeria japonica; CJ) pollinosis has been reported in Japanese monkeys (Macaca fuscata), an appropriate animal model for developing antipollinosis therapies. However, there has been no study on the incidence of Japanese cedar pollinosis in monkeys. To evaluate the incidence of CJ pollinosis in Japanese monkeys, we investigated the presence of pollinosis symptoms among monkeys in a troop, and the response to CJ allergens in pollinosis monkeys. We examined the presence of pollinosis symptoms in 272 monkeys in a troop throughout the CJ pollination season (February to April). Of the 272 monkeys, 21 (7.7%) showed pollinosis symptoms during the CJ pollen season. Blood samples were taken from the 21 monkeys that showed pollinosis symptoms and were tested for the presence of immunoglobulin E (IgE) antibody for CJ allergens. All 21 monkeys with CJ pollinosis had anti-CJ IgE. Of the 21 monkeys, peripheral blood mononuclear cells (PBMC) could be taken from 12, all of which showed CJ allergen-specific PBMC proliferation. The incidence of CJ pollinosis in a troop was 7.7%. The monkeys with CJ pollinosis demonstrated specific IgE and PBMC proliferation for CJ allergens.

摘要

日本猕猴（Macaca fuscata）是开发抗花粉症疗法的合适动物模型，已有报道称其会自然发生日本柳杉（Cryptomeria japonica；CJ）花粉症。然而，尚未有关于猕猴中日本柳杉花粉症发病率的研究。为评估日本猕猴中CJ花粉症的发病率，我们调查了一群猕猴中花粉症症状的出现情况，以及花粉症猕猴对CJ过敏原的反应。我们在整个CJ授粉季节（2月至4月）检查了一群272只猕猴中花粉症症状的出现情况。在这272只猕猴中，有21只（7.7%）在CJ花粉季节出现了花粉症症状。从出现花粉症症状的21只猕猴中采集血样，检测针对CJ过敏原的免疫球蛋白E（IgE）抗体的存在情况。所有21只患有CJ花粉症的猕猴都有抗CJ IgE。在这21只猕猴中，有12只可以采集外周血单个核细胞（PBMC），所有这些细胞都显示出CJ过敏原特异性PBMC增殖。一群猕猴中CJ花粉症的发病率为7.7%。患有CJ花粉症的猕猴表现出针对CJ过敏原的特异性IgE和PBMC增殖。