Sackstein R
Division of Bone Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612-9497, USA.
Acta Haematol. 1997;97(1-2):22-8. doi: 10.1159/000203656.
The process of hematopoiesis is dependent on discrete cell-cell and cell-matrix interactions which are tightly regulated by expression of adhesion molecules. L-selectin, an adhesion protein best known for regulating leukocyte attachment to endothelium, is characteristically expressed on the earliest hematopoietic progenitor cells. Ligands for L-selectin have been extensively characterized on endothelial cells. We recently identified a ligand for L-selectin expressed on the human hematopoietic progenitor cell line KG1a. This molecule is an integral membrane glycoprotein which is structurally different from all ligands previously described. We hypothesize that this molecule may mediate L-selectin-specific adhesive interactions during hematopoiesis. This article discusses the biology of L-selectin and its ligands, and reviews our current understanding of the structure and distribution of the L-selectin ligand expressed on hematopoietic cells.
造血过程依赖于离散的细胞-细胞和细胞-基质相互作用，这些相互作用由黏附分子的表达严格调控。L-选择素是一种黏附蛋白，以调节白细胞与内皮细胞的附着而闻名，其特征性地表达于最早的造血祖细胞上。L-选择素的配体已在内皮细胞上得到广泛表征。我们最近在人造血祖细胞系KG1a上鉴定出一种L-选择素的配体。该分子是一种整合膜糖蛋白，其结构与先前描述的所有配体均不同。我们推测该分子可能在造血过程中介导L-选择素特异性黏附相互作用。本文讨论了L-选择素及其配体的生物学特性，并综述了我们目前对造血细胞上表达的L-选择素配体的结构和分布的理解。
