Alvarez R G, Mesa M G
Agents Actions. 1981 Apr;11(1-2):89-93. doi: 10.1007/BF01991466.
Two vitamins, ascorbic acid (AA) and pyridoxine have been suggested by others as useful drugs for the treatment of bronchial asthma, although the views concerning AA or controversial. We have tested both vitamins in some models of histamine release and experimental anaphylaxis. AA does not inhibit mast cell degranulation induced by phospholipase A and histamine release from isolated rat mast cells induced by compound 48/80 or antigen (egg albumin). On the contrary, in the latter tests pyridoxine exerts inhibition in a range of concentrations from 10(-3)-10(-2) M. We conclude: 1. There is no experimental basis for considering ascorbic acid as a prophylactic antiasthmatic drug as is disodium cromoglycate. 2. Pyridoxine must receive additional basic and clinical investigations in this field.
其他人曾提出两种维生素，即抗坏血酸（AA）和吡哆醇，可作为治疗支气管哮喘的有效药物，尽管关于抗坏血酸的观点存在争议。我们已在一些组胺释放模型和实验性过敏反应中对这两种维生素进行了测试。抗坏血酸不抑制由磷脂酶A诱导的肥大细胞脱颗粒，也不抑制由化合物48/80或抗原（卵清蛋白）诱导的离体大鼠肥大细胞释放组胺。相反，在后者的测试中，吡哆醇在10（-3）-10（-2）M的浓度范围内发挥抑制作用。我们得出结论：1. 没有实验依据将抗坏血酸视为像色甘酸钠那样的预防性抗哮喘药物。2. 吡哆醇在该领域必须接受更多的基础和临床研究。
