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氟喹诺酮类药物在大肠杆菌中诱导DnaK和GroEL热休克蛋白的产生。

Induction of DnaK and GroEL heat shock proteins by fluoroquinolones in Escherichia coli.

作者信息

Mizushima T, Matsuo M, Sekimizu K

机构信息

Department of Microbiology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

出版信息

Antimicrob Agents Chemother. 1997 Jan;41(1):193-5. doi: 10.1128/AAC.41.1.193.

DOI:10.1128/AAC.41.1.193
PMID:8980780
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC163685/
Abstract

Various fluoroquinolones (norfloxacin, enoxacin, ofloxacin, levofloxacin, and sparfloxacin) induce DnaK and GroEL heat shock proteins in Escherichia coli. The induction is transient, consistent with the kinetics of cellular DNA relaxation. The concentrations of fluoroquinolones required for induction are similar to those required for DNA relaxation and much higher than those required for cell death.

摘要

多种氟喹诺酮类药物（诺氟沙星、依诺沙星、氧氟沙星、左氧氟沙星和司帕沙星）可诱导大肠杆菌中的DnaK和GroEL热休克蛋白。这种诱导是短暂的，与细胞DNA松弛的动力学一致。诱导所需的氟喹诺酮类药物浓度与DNA松弛所需的浓度相似，远高于细胞死亡所需的浓度。

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Antimicrob Agents Chemother. 1997 Jan;41(1):193-5. doi: 10.1128/AAC.41.1.193.
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本文引用的文献

1
Transient relaxation of plasmid DNA in Escherichia coli by fluoroquinolones.氟喹诺酮类药物对大肠杆菌中质粒DNA的瞬时松弛作用
J Pharm Pharmacol. 1996 Sep;48(9):985-7. doi: 10.1111/j.2042-7158.1996.tb06018.x.
2
Co-induction of DNA relaxation and synthesis of DnaK and GroEL proteins in Escherichia coli by expression of LetD (CcdB) protein, an inhibitor of DNA gyrase encoded by the F factor.F因子编码的DNA回旋酶抑制剂LetD（CcdB）蛋白的表达在大肠杆菌中共同诱导DNA松弛以及DnaK和GroEL蛋白的合成。
Mol Gen Genet. 1996 Mar 20;250(5):593-600. doi: 10.1007/BF02174447.
3
Relaxation of supercoiled DNA associated with induction of heat shock proteins in Escherichia coli.大肠杆菌中与热休克蛋白诱导相关的超螺旋DNA松弛
Mol Gen Genet. 1993 Apr;238(1-2):1-5. doi: 10.1007/BF00279523.
4
Identification of DNA topoisomerases involved in immediate and transient DNA relaxation induced by heat shock in Escherichia coli.大肠杆菌中参与热休克诱导的即时和短暂DNA松弛的DNA拓扑异构酶的鉴定。
Mol Gen Genet. 1994 Sep 1;244(5):451-5. doi: 10.1007/BF00583895.
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Loss of flagellation in dnaA mutants of Escherichia coli.大肠杆菌dnaA突变体中鞭毛形成的丧失。
J Bacteriol. 1994 Sep;176(17):5544-6. doi: 10.1128/jb.176.17.5544-5546.1994.
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Temperature shift-up leads to simultaneous and continuous plasmid DNA relaxation and induction of DnaK and GroEL proteins in anaerobically growing Escherichia coli cells.
FEMS Microbiol Lett. 1994 Sep 1;121(3):333-6. doi: 10.1111/j.1574-6968.1994.tb07122.x.
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Molecular mechanisms of DNA gyrase inhibition by quinolone antibacterials.
Adv Pharmacol. 1994;29A:285-304. doi: 10.1016/s1054-3589(08)60550-5.
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4-quinolones and the physiology of DNA gyrase.
Adv Pharmacol. 1994;29A:263-83. doi: 10.1016/s1054-3589(08)60549-9.
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Quinolone mode of action--new aspects.喹诺酮类药物的作用模式——新的方面。
Drugs. 1993;45 Suppl 3:8-14. doi: 10.2165/00003495-199300453-00004.
10
Mechanisms of resistance to quinolones.喹诺酮类药物的耐药机制。
Drugs. 1993;45 Suppl 3:15-23. doi: 10.2165/00003495-199300453-00005.