Elwan O H, Baradah O H, Madkour O, Elwan H, Hassan A A, Elwan F, Mahfouz M, Ali A, Fahmy M
Department of Neurology, Cairo University, Egypt.
J Neurol Sci. 1996 Nov;143(1-2):64-71. doi: 10.1016/s0022-510x(96)00161-x.
Forty-three patients with Parkinson's disease (PD) and thirty-seven normal volunteers were subjected to clinical, neuropsychological, neurophysiological (P300 component of the event-related potentials ERP) and radiological (cranial computerized tomographic scanning CCT) evaluation. Intentional memory was more impaired in PD than in normal controls, more so in the demented group of patients, and was related to enlargement of third ventricular size in CCT. While intentional memory was age related in PD patients, perception was age-related in normal controls. Neither global nor specific cognitive functions were related to duration, severity of parkinsonian motor disability, or depression. However, depression in PD was significantly related to parkinsonian motor disability. P300 latency was more prolonged in PD patients than normal controls. P300 parameters of PD patients were not influenced by age, cognitive functions, duration or severity of motor disability, or depression. The reaction time was the only P300 parameter that was age-related in normal controls. Subcortical atrophy as indicated by CCT was more marked in PD and correlated with age in both patients and controls. Subcortical atrophy was significantly related to cognitive functions in PD but not in normal controls. It was concluded that cognitive impairment in PD could be attributed to complex cognitive changes rather than age. It is a disease process, though not directly related to parkinsonian motor disability or depression. PD differed from normal aging as regards the effect of age on the specific cognitive functions, where in PD patients, age was related to intentional memory, yet in normal controls, it was related to perception. Intentional memory deterioration was found to be specific of PD, being related to subcortical atrophy as well as being more pronounced in the demented group of patients.
对43例帕金森病（PD）患者和37名正常志愿者进行了临床、神经心理学、神经生理学（事件相关电位ERP的P300成分）和放射学（头颅计算机断层扫描CCT）评估。与正常对照组相比，PD患者的有意记忆受损更严重，在痴呆患者组中更是如此，且与CCT上第三脑室大小增大有关。虽然PD患者的有意记忆与年龄有关，但正常对照组的感知与年龄有关。整体或特定认知功能均与帕金森运动障碍的病程、严重程度或抑郁无关。然而，PD患者的抑郁与帕金森运动障碍显著相关。PD患者的P300潜伏期比正常对照组延长。PD患者的P300参数不受年龄、认知功能、运动障碍的病程或严重程度或抑郁的影响。反应时间是正常对照组中唯一与年龄相关的P300参数。CCT显示的皮质下萎缩在PD患者中更明显，且在患者和对照组中均与年龄相关。皮质下萎缩在PD患者中与认知功能显著相关，但在正常对照组中则不然。研究得出结论，PD患者的认知障碍可归因于复杂的认知变化而非年龄。这是一个疾病过程，尽管与帕金森运动障碍或抑郁无直接关系。在年龄对特定认知功能的影响方面，PD与正常衰老不同，在PD患者中，年龄与有意记忆有关，而在正常对照组中，年龄与感知有关。发现有意记忆衰退是PD所特有的，与皮质下萎缩有关，且在痴呆患者组中更明显。
